arcOGEN - Publications

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

arcOGEN Consortium , arcOGEN Collaborators , Zeggini E , Panoutsopoulou K , Southam L , Rayner NW , Day-Williams AG , Lopes MC , Boraska V , Esko T , Evangelou E , Hoffman A , Houwing-Duistermaat JJ , Ingvarsson T , Jonsdottir I , Jonnson H , Kerkhof HJ , Kloppenburg M , Bos SD , Mangino M , Metrustry S , Slagboom PE , Thorleifsson G , Raine EV , Ratnayake M , Ricketts M , Beazley C , Blackburn H , Bumpstead S , Elliott KS , Hunt SE , Potter SC , Shin SY , Yadav VK , Zhai G , Sherburn K , Dixon K , Arden E , Aslam N , Battley PK , Carluke I , Doherty S , Gordon A , Joseph J , Keen R , Koller NC , Mitchell S , O'Neill F , Paling E , Reed MR , Rivadeneira F , Swift D , Walker K , Watkins B , Wheeler M , Birrell F , Ioannidis JP , Meulenbelt I , Metspalu A , Rai A , Salter D , Stefansson K , Stykarsdottir U , Uitterlinden AG , van Meurs JB , Chapman K , Deloukas P , Ollier WE , Wallis GA , Arden N , Carr A , Doherty M , McCaskie A , Willkinson JM , Ralston SH , Valdes AM , Spector TD and Loughlin J

Lancet (London, England) 2012 ; 380 ; 9844 ; 815-23

PUBMED: 22763110 ; PMC: 3443899 ; DOI: 10.1016/S0140-6736(12)60681-3

A variant in MCF2L is associated with osteoarthritis.

Day-Williams AG , Southam L , Panoutsopoulou K , Rayner NW , Esko T , Estrada K , Helgadottir HT , Hofman A , Ingvarsson T , Jonsson H , Keis A , Kerkhof HJ , Thorleifsson G , Arden NK , Carr A , Chapman K , Deloukas P , Loughlin J , McCaskie A , Ollier WE , Ralston SH , Spector TD , Wallis GA , Wilkinson JM , Aslam N , Birell F , Carluke I , Joseph J , Rai A , Reed M , Walker K , arcOGEN Consortium , Doherty SA , Jonsdottir I , Maciewicz RA , Muir KR , Metspalu A , Rivadeneira F , Stefansson K , Styrkarsdottir U , Uitterlinden AG , van Meurs JB , Zhang W , Valdes AM , Doherty M and Zeggini E

American journal of human genetics 2011 ; 89 ; 3 ; 446-50

PUBMED: 21871595 ; PMC: 3169824 ; DOI: 10.1016/j.ajhg.2011.08.001

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.

Evangelou E , Valdes AM , Kerkhof HJ , Styrkarsdottir U , Zhu Y , Meulenbelt I , Lories RJ , Karassa FB , Tylzanowski P , Bos SD , arcOGEN Consortium , Akune T , Arden NK , Carr A , Chapman K , Cupples LA , Dai J , Deloukas P , Doherty M , Doherty S , Engstrom G , Gonzalez A , Halldorsson BV , Hammond CL , Hart DJ , Helgadottir H , Hofman A , Ikegawa S , Ingvarsson T , Jiang Q , Jonsson H , Kaprio J , Kawaguchi H , Kisand K , Kloppenburg M , Kujala UM , Lohmander LS , Loughlin J , Luyten FP , Mabuchi A , McCaskie A , Nakajima M , Nilsson PM , Nishida N , Ollier WE , Panoutsopoulou K , van de Putte T , Ralston SH , Rivadeneira F , Saarela J , Schulte-Merker S , Shi D , Slagboom PE , Sudo A , Tamm A , Tamm A , Thorleifsson G , Thorsteinsdottir U , Tsezou A , Wallis GA , Wilkinson JM , Yoshimura N , Zeggini E , Zhai G , Zhang F , Jonsdottir I , Uitterlinden AG , Felson DT , van Meurs JB , Stefansson K , Ioannidis JP , Spector TD and Translation Research in Europe Applied Technologies for Osteoarthritis (TreatOA)

Annals of the rheumatic diseases 2011 ; 70 ; 2 ; 349-55

PUBMED: 21068099 ; PMC: 3615180 ; DOI: 10.1136/ard.2010.132787

Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study.

Panoutsopoulou K , Southam L , Elliott KS , Wrayner N , Zhai G , Beazley C , Thorleifsson G , Arden NK , Carr A , Chapman K , Deloukas P , Doherty M , McCaskie A , Ollier WE , Ralston SH , Spector TD , Valdes AM , Wallis GA , Wilkinson JM , Arden E , Battley K , Blackburn H , Blanco FJ , Bumpstead S , Cupples LA , Day-Williams AG , Dixon K , Doherty SA , Esko T , Evangelou E , Felson D , Gomez-Reino JJ , Gonzalez A , Gordon A , Gwilliam R , Halldorsson BV , Hauksson VB , Hofman A , Hunt SE , Ioannidis JP , Ingvarsson T , Jonsdottir I , Jonsson H , Keen R , Kerkhof HJ , Kloppenburg MG , Koller N , Lakenberg N , Lane NE , Lee AT , Metspalu A , Meulenbelt I , Nevitt MC , O'Neill F , Parimi N , Potter SC , Rego-Perez I , Riancho JA , Sherburn K , Slagboom PE , Stefansson K , Styrkarsdottir U , Sumillera M , Swift D , Thorsteinsdottir U , Tsezou A , Uitterlinden AG , van Meurs JB , Watkins B , Wheeler M , Mitchell S , Zhu Y , Zmuda JM , arcOGEN Consortium , Zeggini E and Loughlin J

Annals of the rheumatic diseases 2011 ; 70 ; 5 ; 864-7

PUBMED: 21177295 ; PMC: 3070286 ; DOI: 10.1136/ard.2010.141473

The effect of genome-wide association scan quality control on imputation outcome for common variants.

Southam L , Panoutsopoulou K , Rayner NW , Chapman K , Durrant C , Ferreira T , Arden N , Carr A , Deloukas P , Doherty M , Loughlin J , McCaskie A , Ollier WE , Ralston S , Spector TD , Valdes AM , Wallis GA , Wilkinson JM , arcOGEN consortium , Marchini J and Zeggini E

European journal of human genetics : EJHG 2011 ; 19 ; 5 ; 610-4

PUBMED: 21267008 ; PMC: 3083623 ; DOI: 10.1038/ejhg.2010.242