arcOGEN Investigators
John Loughlin
Professor of Musculoskeletal Research, Newcastle University; principal investigator
John is a member of the Institute of Cellular Medicine at Newcastle University and carries out molecular genetic, genomic and functional analyses of a number of diseases of the musculoskeletal system.
Nigel Arden
Clinical Reader in Rheumatology and Musculoskeletal Science, University of Oxford; Professor in Rheumatic Diseases, University of Southampton
Nigel's current main focus is predicting the clinical outcome of patients with large joint osteoarthritis and also of the success of lower limb joint replacement surgery. His research programme clusters around outcomes of arthroplasty, prediction of the progression of osteoarthritis, genetics of osteoarthritis and pain and epidemiology of osteoarthritis.
Fraser Birrell
Honorary Clinical Senior Lecturer Musculoskeletal Research Group, Newcastle University
Fraser's primary research interests are in the population occurrence, prediction, impact and treatment of osteoarthritis.
Andrew Carr
Nuffield Professor of Orthopaedic Surgery and Director of the NIHR Biomedical Research Unit, University of Oxford
Andy's research interests include evaluating outcome after joint surgery, developing novel approaches to surgery, and assessing the effect of ageing on musculoskeletal tissues.
Kay Chapman
Botnar Fellow, University of Oxford
Kay's main interest is in the genetics of complex musculoskeletal traits, primarily osteoarthritis.
Panos Deloukas
Group Leader, Genetics of complex traits in humans, The Wellcome Trust Sanger Institute
Panos leads the Genetics of complex traits in humans Group, whose focus is on coronary artery disease and myocardial infarction.
Michael Doherty
Professor of Rheumatology, University of Nottingham
Michael's special research interests are in osteoarthritis, crystal arthritis and evidence-based medicine
Andrew McCaskie
Professor of Orthopaedic Surgery, Newcastle University
Andrew's is a clinical academic with an interest in the surgical treatment of osteoarthritis, particularly improvement in the performance of lower limb joint replacement. His basic science research focuses on cell interaction with biomaterials. He is currently exploring ways in which this can be used in tissue engineering therapies for arthritis.
Bill Ollier
Professor of Immunogenetics, The University of Manchester
Bill's research interests include immunogenetics and genetic control of immune regulation, analysis of complex phenotypes especially autoimmune and inflammatory conditions, gene-environment interactions, high-throughput genotyping, transcriptomics and molecular genetic technologies, and large-scale DNA archiving and clinical data storage.
Ashok Rai
Consultant Rheumatologist and Clinical Director Rheumatology, Worcestershire Acute Hospitals NHS Trust
Ashok's main research interests focus on the aetiology of premature osteoarthritis.
Stuart Ralston
Professor of Rheumatology, University of Edinburgh
Stuart's research focuses on several aspects of bone disease including the genetics of osteoporosis; the pathogenesis and management of Paget's disease of bone; the role of Nitric Oxide in bone, the role of the endocannabinoid system in bone and the pathogenesis and management of cancer-associated bone disease.
Tim Spector
Professor of genetic epidemiology and director of the Department of Twin Research, King's College London
Tim's main interests are gene discovery via genetic epidemiology, and the study of age related diseases such as cardiometabolic traits, locomotor problems, cognitive function and eye disorders. Tim coordinates the TreatOA consortium.
Ana Valdes
Senior Lecturer, Dept of Twin Research and Genetic Epidemiology, King's College London
Ana's research interests focus on the genetics of osteoarthritis and type 1 diabetes.
Gillian Wallis
Professor of genetics, University of Manchester
Gillian's research interests include identifying regulators of joint development and the molecular basis of joint disorders.
Mark Wilkinson
Professor of Orthopaedics, University of Sheffield
Mark's research includes investigating the causes of osteoarthritis and the biological interactions between patients and their artificial joint prostheses, to better understanding the causes and treatments for joint arthritis.
Eleftheria Zeggini
Group Leader, Applied statistical genetics, The Wellcome Trust Sanger Institute
Ele's work aims to help elucidate the genetic determinants of complex human traits by using next-generation association studies to identify novel disease loci.