arcOGEN - Investigators

John Loughlin

Professor of Musculoskeletal Research, Newcastle University; principal investigator

John is a member of the Institute of Cellular Medicine at Newcastle University and carries out molecular genetic, genomic and functional analyses of a number of diseases of the musculoskeletal system.

Nigel Arden

Clinical Reader in Rheumatology and Musculoskeletal Science, University of Oxford; Professor in Rheumatic Diseases, University of Southampton

Nigel's current main focus is predicting the clinical outcome of patients with large joint osteoarthritis and also of the success of lower limb joint replacement surgery. His research programme clusters around outcomes of arthroplasty, prediction of the progression of osteoarthritis, genetics of osteoarthritis and pain and epidemiology of osteoarthritis.

Fraser Birrell

Honorary Clinical Senior Lecturer Musculoskeletal Research Group, Newcastle University

Fraser's primary research interests are in the population occurrence, prediction, impact and treatment of osteoarthritis.

Andrew Carr

Nuffield Professor of Orthopaedic Surgery and Director of the NIHR Biomedical Research Unit, University of Oxford

Andy's research interests include evaluating outcome after joint surgery, developing novel approaches to surgery, and assessing the effect of ageing on musculoskeletal tissues.

Kay Chapman

Botnar Fellow, University of Oxford

Kay's main interest is in the genetics of complex musculoskeletal traits, primarily osteoarthritis.

Panos Deloukas

Group Leader, Genetics of complex traits in humans, The Wellcome Trust Sanger Institute

Panos leads the Genetics of complex traits in humans Group, whose focus is on coronary artery disease and myocardial infarction.

Michael Doherty

Professor of Rheumatology, University of Nottingham

Michael's special research interests are in osteoarthritis, crystal arthritis and evidence-based medicine

Andrew McCaskie

Professor of Orthopaedic Surgery, Newcastle University

Andrew's is a clinical academic with an interest in the surgical treatment of osteoarthritis, particularly improvement in the performance of lower limb joint replacement. His basic science research focuses on cell interaction with biomaterials. He is currently exploring ways in which this can be used in tissue engineering therapies for arthritis.

Bill Ollier

Professor of Immunogenetics, The University of Manchester

Bill's research interests include immunogenetics and genetic control of immune regulation, analysis of complex phenotypes especially autoimmune and inflammatory conditions, gene-environment interactions, high-throughput genotyping, transcriptomics and molecular genetic technologies, and large-scale DNA archiving and clinical data storage.

Ashok Rai

Consultant Rheumatologist and Clinical Director Rheumatology, Worcestershire Acute Hospitals NHS Trust

Ashok's main research interests focus on the aetiology of premature osteoarthritis.

Stuart Ralston

Professor of Rheumatology, University of Edinburgh

Stuart's research focuses on several aspects of bone disease including the genetics of osteoporosis; the pathogenesis and management of Paget's disease of bone; the role of Nitric Oxide in bone, the role of the endocannabinoid system in bone and the pathogenesis and management of cancer-associated bone disease.